Des Moines, IA → St. Louis, MO
273 mi · 5h 27m (driving)
Current Risk
High Risk
Flood Watch in effect — consider delaying
Des Moines
61°
Davis County
60°
Ralls County
61°
St. Louis
60°
Trip Briefing
3 segments · 273 mi · 5h 28m
Weather
⛅ Partly cloudy
60°F, wind 9 mph
Rest Stops
2
Truck svc
Clear driving conditions expected
Rest stops in this segment:
- ● QuikTrip
- ● Flying J Travel Center
Weather May Slow Traffic
Active weather advisory — expect slower travel
Traffic Cameras
See recent road conditions along your route
Images are snapshots updated periodically by state DOTs. Timestamps shown in images indicate when each photo was captured.
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Via I-235 East → US-61
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I-70 at Stan Musial Bridge (#8074)
IL · EB
Martin Luther King Bridge (#8006)
IL · EB
I-55/64 at Milepost 1.7 (#8042)
IL · EB
Rest Stops Along Your Route
14 stops available
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Get Weather Alerts for This Route
We'll notify you when conditions change before your trip. Never drive into a surprise storm again.
⚡ Recent Weather Events on This Route
Premium users received alerts for these conditions:
- 🌧️Sep 27: Rain advisory for afternoon departures
- ❄️Sep 25: Snow expected at higher elevations - consider earlier departure
- 🌫️Sep 22: Dense fog warning for morning travel
Don't miss the next alert →
Driving from Des Moines, IA to St. Louis, MO covers 273 miles in roughly 5h 27m of drive time, crossing state lines. We track 3 live traffic cameras, 14 rest areas and 1 active weather alert along this corridor so you can plan around them. Most drivers do this trip in one day; weather along the route matters more than the forecast at either endpoint, since you'll cross several climate zones.
7-Day Driving Outlook
Today
Sep 29
77° / 59°
No precip
Tomorrow
Sep 30
74° / 65°
No precip
Thu
Oct 1
70° / 65°
No precip
Fri
Oct 2
66° / 52°
No precip
Sat
Oct 3
65° / 49°
No precip
Sun
Oct 4
69° / 52°
No precip
Mon
Oct 5
63° / 46°
No precip
🗓️ Weekend Outlook
Saturday
Good to Go☁️ Overcast at origin, ⛅ Partly cloudy at destination
Sunday
Good to Go☁️ Overcast at origin, ☀️ Clear sky at destination
Plan This Route
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Current Conditions
Des Moines, IA
61°F
Wind: 6 mph
St. Louis, MO
60°F
Wind: 5 mph
Weather data updated in real-time
Driving from Des Moines, IA to St. Louis, MO
The 273-mile drive from Des Moines, Iowa to St. Louis, Missouri takes approximately 5h 27m under normal conditions. Weather along this route can vary significantly, especially across open plains where severe weather and high winds can develop quickly. Route Outlook helps you find the safest time to travel by showing you weather conditions at every point along your route, timed to when you'll actually be there.
This moderate route crosses state lines from Iowa into Missouri, connecting Des Moines and St. Louis. A drive of 273 miles means you'll pass through multiple weather zones. Conditions at your starting point may bear little resemblance to what you'll encounter halfway through the trip.
Common Weather Hazards on This Route
- Sudden rain showers reducing visibility
- High winds affecting vehicle stability
- Seasonal weather changes impacting road conditions
Seasonal Driving Considerations
The Midwest corridor of this route is susceptible to rapid weather changes. Severe thunderstorms and tornadoes are a real threat from April through June, while winter brings heavy lake-effect snow, ice storms, and dangerously low wind chill. Flat terrain means high crosswinds can affect vehicle stability year-round, especially for taller vehicles. Spring flooding can also close highway underpasses and low-lying road segments.
Best Time to Drive Des Moines to St. Louis
For medium-distance drives like this 273-mile route, consider starting in the early morning to arrive before afternoon storms develop. Check the 7-day forecast above to find a day with favorable conditions along the entire route.
Driving Strategy
A 273-mile drive from Des Moines to St. Louis takes a significant part of the day. Plan at least one fuel and rest stop along the way. If your route crosses elevation changes or state lines, expect weather conditions to shift mid-trip. Monitor the segment-by-segment forecast rather than just checking destination weather. Starting early in the morning typically avoids afternoon storm development and rush-hour congestion near urban areas.
Pro Tip
Use Route Outlook's departure optimizer to find the best time to leave. Our 4D trajectory engine considers weather at each point along your route at the exact time you'll be there — not just at your destination. It also integrates live data from traffic cameras, DOT 511 feeds, and road weather sensors.
Frequently Asked Questions
How long is the drive from Des Moines to St. Louis?
The drive is approximately 273 miles and takes about 5h 27m under normal traffic and weather conditions. Severe weather can add significant time to your trip.
What's the best day to drive this route?
Based on current forecasts, Sunday, Oct 4 looks ideal. Low chance of precipitation with manageable conditions
Is it safe to drive from Des Moines to St. Louis today?
Current conditions show high risk along this route. Conditions look favorable for travel. Always stay alert and adjust speed for changing conditions.
Are there rest areas on the Des Moines to St. Louis route?
Yes, there are 14 rest areas along this route. Facilities include restrooms, parking, and in some cases picnic areas and vending machines. Rest stops are spaced throughout the drive, so you'll never be too far from a break.
Can I see live traffic cameras on this route?
Yes, Route Outlook shows 3 live traffic cameras along this route, sourced from state DOT feeds. You can check road visibility, traffic flow, and pavement conditions in real time before and during your drive.
What highways does this route use?
This route primarily uses Other. Conditions can vary between highway segments, so check live camera feeds and road condition reports for each stretch before departing.
Are there any road closures on this route right now?
No significant incidents or road closures are currently reported along this route. Conditions can change quickly — this page updates automatically with the latest data from state DOT 511 systems.
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