Largo, FL → Key West, FL

Your drive from Largo to Key West covers approximately 238 miles and takes roughly four hours and forty-five minutes, representing one of America's most geographically dramatic road trips. Beginning in Largo on Florida's Tampa Bay area, you'll head south on US Highway 19 before transitioning to Florida's Turnpike, which carries you through the central spine of the peninsula. As you progress southward, the landscape gradually transforms from suburban sprawl and modest elevation changes into increasingly tropical terrain. The final and most iconic stretch involves connecting to the Overseas Highway (US Route 1), the legendary road that literally drives you across the water on a series of bridges linking the Florida Keys.

Once you leave the mainland and enter the Keys, you'll experience one of the most unique driving environments in the country. The Overseas Highway stretches approximately 113 miles from Key Largo to Key West, featuring numerous causeways and bridges—including the famous Seven Mile Bridge—that connect the individual islands of the Florida Keys. The terrain here is dramatically different from the mainland: you're essentially driving at sea level through a subtropical island chain with mangrove shorelines, turquoise waters visible on both sides, and minimal elevation throughout. You'll pass through charming island communities like Key Largo, Islamorada, and Marathon, each offering their own character and occasional roadside attractions that tempt drivers to pull over and explore.

Practically speaking, this route contains minimal elevation changes but does transition from busy urban and interstate driving to a slower, more deliberate pace once you reach the Overseas Highway. The drive through the Keys requires patience, as you'll encounter lower speed limits (often 45 mph or less through island towns) and frequent traffic during peak seasons. Winter months from November through March offer the most pleasant driving conditions, with comfortable temperatures and lower humidity, while the summer months bring intense heat, humidity, and afternoon thunderstorms that can make the journey feel longer and more challenging.

The 238-mile drive from Largo, Florida to Key West, Florida takes approximately 4h 45m under normal conditions. Weather along this route can vary significantly, especially along coastal regions where fog and marine weather can impact visibility. Route Outlook helps you find the safest time to travel by showing you weather conditions at every point along your route, timed to when you'll actually be there.

Common Weather Hazards on This Route

• Severe thunderstorms and flash flooding (spring and summer)
• Hurricane and tropical storm impacts (June through November)

Seasonal Driving Considerations

Coastal weather on this route can shift quickly. Marine fog is common during morning hours, especially in spring and fall, reducing visibility to near zero. Hurricane season (June through November) can bring extended road closures and dangerous conditions. During fair weather, coastal routes offer scenic driving — but always verify conditions with live traffic cameras before heading out.

Best Time to Drive Largo to Key West

For medium-distance drives like this 238-mile route, consider starting in the early morning to arrive before afternoon storms develop. Check the 7-day forecast above to find a day with favorable conditions along the entire route.

Driving Strategy

A 238-mile drive from Largo to Key West takes a significant part of the day. Plan at least one fuel and rest stop along the way. If your route crosses elevation changes or state lines, expect weather conditions to shift mid-trip. Monitor the segment-by-segment forecast rather than just checking destination weather. Starting early in the morning typically avoids afternoon storm development and rush-hour congestion near urban areas.

Frequently Asked Questions